Is persisting antigen responsible for the chronicity of experimental allergic arthritis?
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چکیده
منابع مشابه
Is persisting antigen responsible for the chronicity of experimental allergic arthritis?
Animals were injected intra-articularly with antigen after prior immunization with that antigen in Freund's incomplete adjuvant in order to precipitate immune complexes in the surfaces of menisci, ligaments, and cartilage. On reimmunization with antigen in Freund's complete adjuvant 10 weeks later, generally an arthritis limited to the intercondylar fossa developed; but on intra-articular injec...
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15 صفحه اولCationic Yersinia antigen-induced chronic allergic arthritis in rats. A model for reactive arthritis in humans.
Cationic antigens are known to have considerable arthritogenic potential in experimental systems. During a systematic search for suitable, naturally occurring candidates an intracellular protein was isolated from the ribosomal pellet of Yersinia enterocolitica 0:3, a bacterial strain associated with reactive arthritis in humans. The protein is highly cationic, contains two 19-kD polypeptide cha...
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In an experimental arthritis induced by injection of bovine serum albumin or egg albumin into the joints of previously immunized animals, it has been demonstrated that the major portion of the radioactively labeled antigens injected was localized to avascular collagenous tissues in the joint, i.e., articular cartilage, menisci, and intra-articular ligaments. The antigens were partially eluted f...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1977
ISSN: 0003-4967
DOI: 10.1136/ard.36.1.34